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41 pictures and 114 papers on the adipocyte: the pictures by method, the papers by section. A picture opens large on a click and goes to its paper on a second. Every PMID adipo.site cites (243) is checked against PubMed for retractions at each build: none found.

Electron microscopy 15

Perirenal adipose tissue in yak calves (H&E, panels A-B; SEM, Oil Red O and UCP1 IHC, panels C-I). Postnatal day 1 and day 30 sections show multilocular brown adipocytes (black arrows) with smaller lipid droplets and mitochondria-rich cytoplasm, contrasting with the large unilocular white adipocytes in the surrounding depot.

Bai Z, Fan W, Hao L et al. Front Vet Sci. 2026;13:1710538. PMID: 42052336 · CC BY 4.0

Transmission electron microscopy of dedifferentiated fat (DFAT) cells derived from human adipose tissue. After 7 days of ceiling culture on ACLAR, cells show multiple lipid droplets (L), mitochondria (M), nucleus (N), and collagen (C), demonstrating adipocyte plasticity and return to a progenitor-like state.

Ostinelli G, Gauthier MF, Vernoux N et al. Front Cell Dev Biol. 2025;13:1547836. PMID: 40406419 · CC BY 4.0

Cordycepin comprehensively restores mitochondrial quality control and homeostasis in the brown adipose tissue of mice exposed to constant light. ( A ) Representative transmission electron microscopy (TEM) images showing mitochondrial ultrastructure. Circles highlight damaged mitochondria exhibiting fragmented cristae and vacuolization. Scale bars: 2 um (upper) and 500 nm (lower). ( B ) Quantification of total reactive oxygen species (ROS); ( C ) mitochondrial ROS (mtROS); ( D ) lipid peroxidation product malondialdehyde (MDA); ( E ) total superoxide dismutase (SOD) enzymatic activity; ( F ) relative mitochondrial DNA (mtDNA) copy number; ( G ) total ATP content in BAT homogenates. ( H - J ) relative mRNA expression of genes related to biogenesis (Nrf1, Tfam), mitophagy (Pink1, Parkin) and genes regulating mitochondrial dynamics (Mfn1, Mfn2, Drp1); ( K - O ) representative Western blot and corresponding densitometric quantifications showing protein levels of NRF1, TFAM, total DRP1, and p-DRP1 Ser616 ( K - M ), and markers of mitophagic flux including the LC3-II/LC3-I and p62 degradation ( N , O ). Tubulin was used as a loading control for Western blots. Data are presented as mean +/- SD with individual data points shown (n = 6 mice per group for physiological and molecular assays; n = 3 mice per group for Western blot). Statistical significance was determined by one-way ANOVA followed by Tukey's post hoc test (* p < 0.05, ** p < 0.01, *** p < 0.001).

Bi, Zhang, Wang et al 2026, International Journal of Molecular Sciences · CC BY 4.0

E4BP4 prevents obesity-induced mitochondrial fragmentation. (A) Transmission electron microscopy (TEM) of mitochondrial morphology in iBAT at 28-29 degrees C in Control and E4BP4-OE mice after 10 weeks of HFD feeding. Representative image. Scale bar: 2 um. Red arrows show mitochondria. (B) Kernel density plot of maximal mitochondrial length of (A). (C) Quantification of maximal mitochondrial length (n = 3 per group). Data were presented as mean +/- SEM. (D) Schematic illustration of experimental design for (E). (E) Right: Images of mitochondrial morphology in primary brown adipocytes by TOM20 immunofluorescence after 24 h of control treatment (BSA) or palmitate stimulation (BSA:PAL). Representative image. Scale bar, 10 um. Left: Quantification of cells with a fragmented mitochondrial network (n = 4; 100-220 mitochondria from ten images/group/experiment). Data were presented as mean +/- SEM. (G) Left: live-cell fluorescence of MitoDendra2 in primary brown adipocytes infected with AAV-control or E4BP4. Representative image. Scale bar, 12 um. Right: Quantification of colocalization of Dendra active and not-activated. Data were presented as mean +/- SEM. (H) Oxygen consumption rate (OCR) in differentiated primary brown adipocytes expressing Control or E4bp4 after pretreatment for 6 h with control treatment (BSA) or palmitate stimulation (BSA:PAL).

Valdivieso-Rivera, Furino, Leher et al 2026, EMBO Reports · CC BY 4.0

Deficiency of Ccr1 increases adaptive thermogenesis of cold-stimulated mice. (A) Relative mRNA expression of Ccr1 in the adipose tissues of 4°C-stimulated mice (n = 4). (B) Rectal temperature of mice (n = 4). (C) Uncoupling protein 1 (UCP1)-stained brown adipose tissue (BAT) sections of mice (n = 4). Scale bars = 100 um. (D) Immunoblots of UCP1, p-PKA-C and p-CREB and their total proteins in BAT of 4°C-stimulated mice (n = 4). (E) Relative mRNA levels of thermogenic genes in BAT of mice (n = 4). (F) UCP1-stained inguinal white adipose tissue (iWAT) sections of mice (n = 4). Scale bars = 100 um. (G) Immunoblots of UCP1, p-PKA-C and p-CREB and their total proteins in iWAT of mice (n = 4). (H) Relative mRNA levels of thermogenic genes in iWAT of 4°C-stimulated mice (n = 4). Data are presented as mean +/- SEM. (B-H) Two-tailed Student's t-test. *p < .05, **p < .01.

Cai, Ma, Zhu et al 2026, Clinical and Translational Medicine · CC BY 4.0

Confocal analysis of visceral adipose tissue from rats with MASLD treated with CDPs. ( A ) Representative confocal microscopy images of visceral adipose tissue sections stained with Propidium Iodide (PI), MitoTracker Green, and anti-UCP1 antibody, with clear-field images shown (20x magnification). Scale bar = 50 um. Animal groups are defined in Figure 2 . ( B ) Quantification of fluorescence intensity using MitoTracker Green staining and UCP1 immunodetection. VAT samples from six animals per animal group ( n = 6) were dissected and processed for staining. Fifteen representative microscopic fields acquired from the six animals in each experimental group were analyzed to quantify fluorescence. Bars represent the means +/- SEM, n = 6 animals per group. Statistical analysis was performed using one-way ANOVA, followed by Tukey's post hoc test. Different lowercase letters indicate significant differences ( p < 0.05).

Figueroa-Guzman, Campos-Morales, Martinez-Alcantar et al 2026, Molecules · CC BY 4.0

MAM-LD architecture is strongly altered in the inguinal adipose tissue of Seipin-deficient mice. ( A - D ) Inguinal adipose tissue was collected from Bscl2 (Control) and lox/lox Bscl2 lox/lox ERT2-Adipoq-Cre (iATSKO) mice in the random-fed state, 14 days after tamoxifen injection (100 mg/kg). Transmission electron microscopy (TEM) images were analyzed, and the contact surface areas of mitochondria-associated membranes (MAMs), mitochondria-lipid droplet (Mi-LD), and endoplasmic reticulum-lipid droplet (ER-LD) interfaces were quantified using Fiji, as described in the Materials and Methods. ( E - F ) MAM subpopulations were quantified according to their proximity to lipid droplets: MAM-LD (<50 nm from LDs) and MAM-CM (>50 nm from LDs). ( G, H ) MAM abundance was quantified using proximity ligation assay (PLA) for IP3R and VDAC, combined with PLIN1 immunofluorescence and structured illumination microscopy (SIM). Representative images show PLIN1 (gray), MAM-LD (magenta), and MAM-CM (pink) ( G ). Total PLA signals were quantified and classified according to their distance from lipid droplets: MAM-LD (<380 nm from LDs) and MAM-CM ( >380 nm from LDs) ( H ). ( I ) Representative focused ion beam-scanning electron microscopy (FIB-SEM) images of adipose tissue sections from Control and iATSKO mice. Organelle segmentation shows mitochondria (orange), lipid droplets (yellow), nucleus (blue), and plasma membrane (white). ( J - M ) Cryopreserved subcutaneous adipose tissue from Control and iATSKO mice in the fed or 18 h fasted state was analyzed by PLIN1 immunofluorescence ( J ). PLA was used to quantify MAMs (VDAC/IP3R; K ), Mi-LD contacts (PTPIP51/PLIN1; L ), and ER-LD contacts (VAPB/PLIN1; M ). ( N, O ) Lipid droplets were isolated from Control and iATSKO mice and subjected to lipidomic analysis.

Palard, Chadeuf, Carpentier et al 2026, The EMBO Journal · CC BY 4.0

MAM-LD architecture is strongly altered in the inguinal adipose tissue of Seipin-deficient mice. (A-D) Inguinal adipose tissue was collected from Bscl2 lox/lox (Control) and Bscl2 lox/lox ERT2-Adipoq-Cre (iATSKO) mice in the random-fed state, 14 days after tamoxifen injection (100 mg/kg). Transmission electron microscopy (TEM) images were analyzed, and the contact surface areas of mitochondria-associated membranes (MAMs), mitochondria-lipid droplet (Mi-LD), and endoplasmic reticulum-lipid droplet (ER-LD) interfaces were quantified. (E-F) MAM subpopulations were quantified according to their proximity to lipid droplets: MAM-LD (< 50 nm from LDs) and MAM-CM (> 50 nm from LDs). (G, H) MAM abundance was quantified using proximity ligation assay (PLA) for IP3R and VDAC, combined with PLIN1 immunofluorescence and structured illumination microscopy (SIM). Representative images show PLIN1 (gray), MAM-LD (magenta), and MAM-CM (pink) (G). (I) Representative focused ion beam-scanning electron microscopy (FIB-SEM) images of adipose tissue sections from Control and iATSKO mice. Organelle segmentation shows mitochondria (orange), lipid droplets (yellow), nucleus (blue), and plasma membrane (white). (J-M) Cryopreserved subcutaneous adipose tissue from Control and iATSKO mice in the fed or 18 h fasted state was analyzed by PLIN1 immunofluorescence (J). PLA was used to quantify MAMs (VDAC/IP3R; K), Mi-LD contacts (PTPIP51/PLIN1; L), and ER-LD contacts (VAPB/PLIN1; M).

Palard, Chadeuf, Carpentier et al 2026, The EMBO Journal · CC BY 4.0

(a) Adipocyte nucleus (N) with a pronounced nucleolus (nu) without indentation in non-lipedema control tissue (sagittal plane). The nucleus appears flat, adapting its form to the curvature of the mature adipocyte and is closely attached to the main lipid droplet (mLD). (b) Lochkern in a lipedema adipocyte (sagittal plane). The bulging of the nucleus, due to the indentation, is seen. Electron optical analysis clearly indicates that the content of the satellite droplet (SD) and the mLD is identical (asterisks). (c) Ultrathin sections showing the contact zone between the nucleus and the SD at the nuclear pore (arrowheads). A mitochondrion is seen within the adipocyte cytoplasm (m). (d) A channel-like stucture connects the SD with the adjacent heterochromatin (arrow) and the nuclear pore contact (arrowhead). (e) High magnification of a strongly extended contact region [462 nm, measured by ImageJ] between a satellite droplet and the nuclear membrane. (f) A Lochkern showing a fenestration for passage of the satellite droplet to the main droplet. Black arrows indicate the opening within the nuclear membrane, white arrowheads point to the dissolution of the phosholipid membrane. (g) A lateral small lipid droplet is fusing (black arrow) with the large satellite droplet. This fusion process (arrowheads) is identical with fusion of normally generated LDs during lipogenesis.

Steiner, Rinnerthaler, Mueller et al 2026, Frontiers in Cell and Developmental Biology · CC BY 4.0

MAM-LD architecture is strongly altered in the inguinal adipose tissue of Seipin-deficient mice. (A-D) Inguinal adipose tissue was collected from Bscl2lox/lox (Control) and Bscl2lox/lox ERT2-Adipoq-Cre (iATSKO) mice in the random-fed state, 14 days after tamoxifen injection (100 mg/kg). Transmission electron microscopy (TEM) images were analyzed, and the contact surface areas of mitochondria-associated membranes (MAMs), mitochondria-lipid droplet (Mi-LD), and endoplasmic reticulum-lipid droplet (ER-LD) interfaces were quantified. (E-F) MAM subpopulations were quantified according to their proximity to lipid droplets: MAM-LD (<50 nm from LDs) and MAM-CM (>50 nm from LDs). (G, H) MAM abundance was quantified using proximity ligation assay (PLA) for IP3R and VDAC, combined with PLIN1 immunofluorescence and structured illumination microscopy (SIM). Representative images show PLIN1 (gray), MAM-LD (magenta), and MAM-CM (pink) (G). (I) Representative focused ion beam-scanning electron microscopy (FIB-SEM) images of adipose tissue sections from Control and iATSKO mice. Organelle segmentation shows mitochondria (orange), lipid droplets (yellow), nucleus (blue), and plasma membrane (white). (J-M) Cryopreserved subcutaneous adipose tissue from Control and iATSKO mice in the fed or 18 h fasted state was analyzed by PLIN1 immunofluorescence (J). PLA was used to quantify MAMs (VDAC/IP3R; K), Mi-LD contacts (PTPIP51/PLIN1; L), and ER-LD contacts (VAPB/PLIN1; M).

Palard, Chadeuf, Carpentier et al 2026, The EMBO Journal · CC BY 4.0

Agnuside reinforces mitochondrial respiratory complex assembly and cristae architecture in thermogenic adipose tissue. (A) Heatmap of protein abundance in BAT from mice exposed to acute cold (4 degrees C, 5 h). Eight-week-old male C57BL/6J mice received daily intraperitoneal injections of AGN (7.5 mg/kg) for 4 weeks before cold exposure. Proteomic data were z-score-normalized and visualized as heatmaps ( n = 4 per group). (B) Representative transmission electron microscopy (TEM) images of BAT mitochondria from mice treated as in (A). Scale bar, 2 um. (C,D) Quantification of mitochondrial diameter (C) and cristae abundance (D) from TEM images shown in (B). n = 300 mitochondria each group in (C), and n = 80 mitochondria each group in (D). (E) ATP content in BAT tissues from mice treated as in (A) ( n = 5 per group). (F) Western blot analysis of representative subunits of mitochondrial respiratory complexes in BAT from mice treated as in (A), with densitometric quantification on the right ( n = 4 per group). (G) Blue native-PAGE (BNPAGE) analysis of isolated BAT mitochondria from mice in (A), with quantification of respiratory complexes shown below ( n = 3 per group). (H,J) Western blot analysis of representative subunits of mitochondrial respiratory complexes in BAT (H) and iWAT (J) from HFD-fed mice treated with AGN, with quantification shown on the right ( n = 4 per group). (I,K) BN-PAGE analysis of mitochondria isolated from BAT (I) and iWAT (K) from HFD-fed mice treated with AGN, with quantification shown on the right ( n = 3 per group). Data, except for panels (A,C,D), are presented as mean +/- SEM. * p < 0.05, ** p < 0.01, *** p < 0.001.

Zhao, Xie, Wang et al 2026, Advanced Science · CC BY 4.0

Orai1 deficiency impairs mitochondrial Ca2+ uptake and structural remodelling during thermogenic activation. (a) Model illustrating that cold-induced Ca2+ influx via Orai1 is essential for mitochondrial Ca2+ uptake and subsequent thermogenesis. (b) Rhod-2 fluorescence imaging of mitochondrial Ca2+ in siCtrl and siOrai1 cells. (c) Quantification of mitochondrial Ca2+ uptake following temperature shifts (37 degrees C to 15 degrees C). (d) Transmission electron microscopy images of BAT from control and brown adipocyte-specific Orai1 knockout (BKO) mice exposed to cold for 6 h. (e) Western blot analysis of oxidative phosphorylation proteins in control and Orai1 BKO brown adipose tissue after cold exposure (4 degrees C) for 6 h. (f) Western blot analysis of oxidative phosphorylation proteins during differentiation of preadipocytes to brown adipocytes treated with siOrai1. (g) Mitochondrial DNA copy number measured in control and Orai1-deficient cells with CL316243 treatment. (h) Oxygen consumption rate (OCR) analysis of Orai1-deficient adipocytes treated with CL316243. (i) Fatty acid oxidation (FAO) assay of Orai1-deficient adipocytes treated with CL316243. Data are presented as mean +/- SEM. Statistical significance *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. FCCP, carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone; FFA, free fatty acid; ns, not significant.

Kim, Nguyen, Park et al 2026, Experimental and Molecular Medicine · CC BY 4.0

WD enhances nuclear localization of SPHK2 in SWAT. ( A ) Representative confocal micrographs of sWAT from 18 week chow or WD fed Sphk2 DeltaAdipo and WT male mice were stained for SPHK2 and counterstained with DAPI and then quantified ( B ) as % SPHK2-stained area per nuclei ( N = 6, n = 8). Data are presented as means +/- SEM; **** P <= 0.0001 compared with WT littermates fed chow diet, unpaired two-tailed t test. ( C ) Representative confocal micrographs of sWAT, gWAT, and BAT from WT mice stained for SPHK2 or UCP1 and counterstained with DAPI and were quantified ( D ) as % SPHK2-stained area per nuclei or as % UCP1-stained area per field ( N = 4, n = 8). ( E ) Chromatin fractions from WT primary white adipocytes were separated by SDS-polyacrylamide gel electrophoresis (PAGE) and immunoblotted with SPHK2-specific antibody. Antibodies against histone H3 and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) were used as markers for chromatin and cytosol. ( F ) Representative immunofluorescence images of WT or Sphk2 knockout (KO) primary adipocytes treated with vehicle or palmitate (500 uM) for 24 hours and were quantified ( G ) as % SPHK2-stained area per nuclei ( N = 6, n = 8). Scale bars, 5 um.

Brown, Weigel, Vijayan et al 2026, Science Advances · CC BY 4.0

WD enhances nuclear localization of SPHK2 in SWAT. (A) Representative confocal micrographs of sWAT from 18 week chow or WD fed Sphk2 DeltaAdipo and WT male mice were stained for SPHK2 and counterstained with DAPI and then quantified (B) as % SPHK2-stained area per nuclei (N = 6, n = 8). Data are presented as means +/- SEM; **** P <= 0.0001 compared with WT littermates fed chow diet, unpaired two-tailed t test. (C) Representative confocal micrographs of sWAT, gWAT, and BAT from WT mice stained for SPHK2 or UCP1 and counterstained with DAPI and were quantified (D) as % SPHK2-stained area per nuclei or as % UCP1-stained area per field (N = 4, n = 8). (E) Chromatin fractions from WT primary white adipocytes were separated by SDS-PAGE and immunoblotted with SPHK2-specific antibody. Antibodies against histone H3 and GAPDH were used as markers for chromatin and cytosol, respectively. (F) Representative immunofluorescence images of WT or Sphk2 knockout (KO) primary adipocytes treated with vehicle or palmitate (500 uM) for 24 hours and were quantified (G) as % SPHK2-stained area per nuclei (N = 6, n = 8). Scale bars, 5 um.

Brown, Weigel, Vijayan et al 2026, Science Advances · CC BY 4.0

Cold Exposure Induces Subcellular Structural Changes in the Inguinal Adipose Tissue of Pigs. ( A , B ) Scanning electron microscopy images of the cold exposure and control groups, with the green arrows indicating multilocular lipid droplets in adipocytes and the purple arrows indicating blood vessels or lymphatic vessels. ( C - G ) Transmission electron microscopy images of the cold exposure and control groups. ( E ) A typical brown adipocyte showing multiple small lipid droplets within the cell and a greater number of mitochondria. ( C , G ) are close-ups of ( E ). ( D ) is a close-up of ( F ). The orange arrows indicate mitochondria.

Guo, Lv, Ma et al 2025, International Journal of Molecular Sciences · CC BY 4.0

Immunostaining and fluorescence 5

The HUVAS culture model facilitates the differentiation of unilocular human white adipocytes in vitro. A: Schematic of 2D, scaffold-free 3D, and scaffolded HUVAS cultures, done side by side using stromal vascular fraction cells from same donor and passage, cultured in the same media and with the same differentiation time, varying only the cell environment. B: Representative confocal images of BODIPY, CellMask, and DAPI-stained adipocytes on day (d)30. Scale bars for all images in Figure 1: 500 um (main), 50 um (inset). C-F: Quantification of lipid droplet diameter (C), total lipid droplet area (D), adipocyte unilocularity (E), and total adipocyte area (F) across isogenic 2D, 3D, and HUVAS cultures from n = 50 cells per spheroid and 3 spheroids per individual. Similar results were obtained from cells from three different cell donors.

Maestri, Cai, Schipper et al 2026, Journal of Lipid Research · CC BY 4.0

Analysis of endogenous PLINs in human adipocyte (TERT-hWA) cultures suggests different modes of interaction with LDs. (A) Time course of adipocyte differentiation. (B) Western blot analysis of adipocyte markers and PLINs during adipocyte differentiation. P: proliferation; D3, D6, and D11: day of differentiation. (C) Representative z sections obtained by confocal fluorescence microscopy of endogenous PLIN1 (blue), PLIN2 (red), and PLIN4 (green) in human adipocytes at day 10 of differentiation after immunofluorescence with specific antibodies, with the nuclei stained with DAPI (white). Bottom panels show the three protein channels in the indicated area. The cells were maintained in culture medium or fed with 100 uM oleic acid for 2.5 h before observation. Scale bar: 10 um. (D) Quantification showing the fraction of cells with PLIN4 signal as indicated under the same conditions as in C. Four categories were defined: cells without detectable PLIN4; cells in which PLIN4 was entirely cytosolic; cells in which PLIN4 was mostly cytosolic but marked a few puncti (possible LDs); cells in which PLIN4 was LD-localized. N of cells quantified was 108 for D3 - OA, 104 for D3 + OA, 92 for D6 - OA, 92 for D6 + OA, 98 for D10 - OA and 93 for D10 + OA, from one of two representative experiments.

Dias Araujo, Bello, Bigay et al 2024, The Journal of Cell Biology · CC BY 4.0

Immunofluorescence localization of PLIN1 on LDs in perirenal adipose tissue of 1- and 30-days-old yak calves: (A-C) Perirenal adipose tissue at 1 day old; (D-F) Perirenal adipose tissue at 30 days old; (G-I) Negative controls. White arrows indicate PLIN1-positive on LD in adipocytes, red arrows indicate nuclei of PLIN1-positive adipocytes. Scale bars: 10 um.

Bai, Fan, Hao et al 2026, Frontiers in Veterinary Science · CC BY 4.0

WD enhances nuclear localization of SPHK2 in SWAT. (A) Representative confocal micrographs of sWAT from 18 week chow or WD fed Sphk2 DeltaAdipo and WT male mice were stained for SPHK2 and counterstained with DAPI and then quantified (B) as % SPHK2-stained area per nuclei (N = 6, n = 8). (C) Representative confocal micrographs of sWAT, gWAT, and BAT from WT mice stained for SPHK2 or UCP1 and counterstained with DAPI and were quantified (D) as % SPHK2-stained area per nuclei or as % UCP1-stained area per field (N = 4, n = 8). (F) Representative immunofluorescence images of WT or Sphk2 knockout (KO) primary adipocytes treated with vehicle or palmitate (500 uM) for 24 hours and were quantified (G) as % SPHK2-stained area per nuclei (N = 6, n = 8). Scale bars, 5 um.

Brown, Weigel, Vijayan et al 2026, Science Advances · CC BY 4.0

CT increased UCP1 expression in iWAT and rpWAT after 8 weeks. (A) Representative immunohistochemistry images of UCP1 staining in iWAT and rpWAT; (B) UCP1 positive-staining area per field (um2) in each adipose tissue depot; and (C) Multilocular adipocyte area normalized to the total WAT area analyzed. Data are presented as mean +/- SD. Comparisons between SED and CT were performed using an unpaired two-tailed Student's t-test. *p < 0.05 versus the corresponding SED group. Scale bars, 50 um. Abbreviations: SED, sedentary (n = 5 animals); CT, combined training (n = 5 animals); WAT, white adipose tissue; iWAT, inguinal white adipose tissue; rpWAT, retroperitoneal white adipose tissue; UCP1, uncoupling protein 1.

Picoli, Gilio, Henriques et al 2026, Journal of Physiology and Biochemistry · CC BY 4.0

Stained sections and smears 12

White adipose tissue, H&E (lipoma section). Mature unilocular adipocytes with the classic signet-ring appearance: large empty spaces after lipid extraction, thin cytoplasm rims, and peripheral haematoxylin-stained nuclei. Fibrous capsule and septal stroma visible.

Hyeree Kim, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim, Wikimedia Commons · CC BY 4.0

White adipose tissue, histological section. Unilocular adipocytes in connective tissue context, showing the lobular architecture of adipose tissue and the relationship between fat cells and their supporting stroma.

Berkshire Community College Bioscience Image Library, Wikimedia Commons · CC0

Brown adipose tissue, histological section. Multilocular adipocytes with smaller lipid droplets and cytoplasm-rich cells, distinct from the unilocular white adipocyte. The denser, more granular cytoplasm reflects the high mitochondrial content that drives UCP1-mediated thermogenesis.

Wikimedia Commons · public domain

White adipose tissue, H&E (inferred). Adipocytes with lipid voids at the centre and peripheral pink nuclei pushed to the cell rim. Ghost-cell morphology is the expected artifact of paraffin processing: lipid dissolves, leaving a clear sphere outlined by a thin cytoplasmic rim and a flattened crescent nucleus.

Echinaceapallida, Wikimedia Commons · CC BY-SA 4.0

Unilocular and Multilocular adipocytes of adipose tissue from rats. (A) Representative histological images of unilocular adipocytes in brown adipose tissue (BAT) and multilocular adipocytes in inguinal (iWAT) and epididymal (eWAT) adipose tissues. Stain: hematoxylin and eosin. Scale bar: 10 μm (BAT) and 5 μm (iWAT and eWAT); (B) Quantification of unilocular adipocytes in BAT and multilocular adipocytes in iWAT and eWAT. Values are presented as box plots with whiskers from minimum to maximum (n = 5/group). *p < 0.05 effect of diet; # p < 0.05 effect of Tucum-do-Cerrado.

Cavalcanti MH, Damazo AS, Arruda SF. Mol Nutr Food Res. 2026;70(13):e70498. PMID: 42377995 · CC BY 4.0

Histological images of adipose tissues of rats. (A) Morphological evaluation of Brown (BAT), inguinal (iWAT), and epididymal (eWAT) adipose tissues. Stain: hematoxylin and eosin. Scale bar: 20 μm (BAT) and 10 μm (iWAT and eWAT). (B) Quantification of unilocular adipocyte area. Values are presented as box plots with whiskers from minimum to maximum (n = 5/group). *p < 0.05 effect of diet; # p < 0.05 effect of Tucum-do-Cerrado.

Cavalcanti MH, Damazo AS, Arruda SF. Mol Nutr Food Res. 2026;70(13):e70498. PMID: 42377995 · CC BY 4.0

Yellow adipose tissue, paraffin section with lipids washed out during processing. The empty round spaces correspond to former lipid droplets dissolved by organic solvents. Thin cytoplasm rims and peripheral nuclei remain. From the Department of Histology, Jagiellonian University Medical College, Krakow.

Department of Histology, Jagiellonian University Medical College, Wikimedia Commons · CC BY-SA 3.0

Lipoblast-like histiocyte in fat necrosis of the breast (H&E). A foamy histiocyte with lightly eosinophilic cytoplasm and a small normochromatic nucleus that is not hollowed out by lipid vacuoles, distinguishing it from a true lipoblast. Olympus LC30, by Mikael Haggstrom, M.D.

Mikael Haggstrom, M.D., Wikimedia Commons · CC0

During differentiation a myriad of adipogenic loci are under the influence of chromatin modifying complexes. This figure outlines 2 major points of regulation of adipogenesis. b) PPARγ target regulation. PPARγ acts on a variety of genes implicated in adipocyte differentiation and function.

Cook, A. and Cowan, C., Adipose (March 31, 2009), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.40.1, http://www.stembook.org . · CC BY 3.0

White adipose tissue, hematoxylin and eosin stain; unilocular adipocytes with peripheral nuclei, fine connective tissue septa

Veeresh likhitha · CC BY-SA 4.0

BIX02189 suppresses adipocyte differentiation and lipid accumulation in 3T3-L1 cells in a dose-dependent manner. (A) Representative phase-contrast and Oil Red O-stained images of 3T3-L1 cells. Preadipocytes (D0) were induced to differentiate and treated with BIX02189 (0, 5, 10, and 20 uM) throughout the differentiation period (D0-D8). Control cells exhibited extensive lipid droplet formation, whereas BIX02189 treatment reduced lipid accumulation in a concentration-dependent manner. (B) Quantitative analysis of intracellular triglyceride (TG) content in differentiated 3T3-L1 adipocytes. TG levels were significantly decreased following BIX02189 treatment in a dose-dependent manner. (C) Cell viability of 3T3-L1 cells treated with BIX02189 for 8 days. Cell survival was expressed as a percentage of the control group. BIX02189 at 5 and 10 uM had minimal effects on cell viability, whereas a moderate reduction was observed at 20 uM. Data are presented as mean +/- SE from at least three independent experiments. * p < 0.05 versus control.

Perumal, Hussain, Son et al 2026, International Journal of Molecular Sciences · CC BY 4.0

H&E staining of white adipose tissue from a murine heart failure model. Large unilocular adipocytes with peripheral flattened nuclei are clearly visible. Section from vehicle-treated control animals.

Ma D 2023, Lipids in health and disease · CC BY 4.0

Light microscopy 4

Differentiated adipocytes (PA6 cell line), light microscopy. Round lipid-laden cells with cytoplasm compressed to a thin rim around the central lipid droplet, demonstrating the characteristic unilocular morphology of the white adipocyte.

M. Oktar Guloglu, Wikimedia Commons · CC BY-SA 4.0

Human adipose tissue cell, light microscopy from a medical college microbiology class. White adipocytes show the unilocular empty space after lipid extraction with a thin cytoplasm rim and peripheral nucleus.

Chalova.lina, Wikimedia Commons · CC BY 4.0

Adipose connective tissue, light micrograph; unilocular white adipocytes with sparse cytoplasm and peripheral nucleus embedded in connective tissue stroma

Berkshire Community College Bioscience Image Library · CC0

Adipose connective tissue cross-section, light micrograph 200x; unilocular white adipocytes showing signet-ring appearance after lipid extraction during processing

Berkshire Community College Bioscience Image Library · CC0

Other micrographs 1

White adipose connective tissue, 200x magnification. Cross section showing lobules of unilocular adipocytes surrounded by thin connective tissue septa. From the Berkshire Community College Bioscience Image Library.

Berkshire Community College Bioscience Image Library via Flickr, Wikimedia Commons · CC0

Figures and diagrams 4

Adipose tissue inflammation in obesity: when an adipocyte hypertrophies beyond its capacity, it undergoes stress and death. Macrophages are recruited and form a crown-like structure around the dead cell, secreting TNF-alpha and IL-6. This diagram shows the lipid-overflow-to-inflammation sequence that links adipocyte hypertrophy to systemic insulin resistance.

Correa et al., Wikimedia Commons · CC BY 4.0

White, brown, and beige adipocytes: structural comparison. White holds a single unilocular lipid droplet with a crescent nucleus pushed to the rim. Brown has multilocular droplets and abundant mitochondria. Beige arises in white depots under cold or adrenergic stimulation and expresses UCP1.

adipo.site · CC0

White adipocyte on H&E: the signet-ring appearance. Lipid is extracted by processing solvents, leaving a large empty space with a thin cytoplasm rim and a peripheral crescent nucleus stained purple with haematoxylin. The empty space is not pathology; it is expected paraffin processing artifact.

adipo.site · CC0

Adipokine outputs of the white adipocyte: leptin, adiponectin, TNF-alpha, IL-6, resistin, and free fatty acids. Each arrow shows the downstream effect: appetite suppression, insulin sensitization, inflammation, IRS-1 serine phosphorylation, and lipotoxicity via ectopic fat deposition.

adipo.site · CC0

Signaling 26

Filed by MeSH heading or keyword; each paper says which one matched. The Signaling page holds the dated feed.

  1. Aboud G, Benson TW, Harb R, Veerapaneni P, Zhang G, Ahmadieh S, et al. Hematopoietic-Specific DARC Deficiency Is Associated with Adipose Tissue Inflammation and Impaired Glucose Tolerance During Diet-Induced Obesity in Mice. Cells. 2026;15:1664. PMID: 42782763. MeSH: Receptors, Cell Surface
  2. So S, Kwon S, Choi Y, Kim DY, Kim MH. High‑fat diet exacerbates hepatic and adipose insulin signaling impairment and ovarian lesions in a rat model of letrozole‑induced polycystic ovary syndrome. Mol Med Rep. 2026;34:308. PMID: 42757461. MeSH: Signal Transduction
  3. Zhang Y, Huang W, Zhang Y, Xia J, Wang Y, Zhang Z, et al. [Electroacupuncture promotes browning of white adipose tissue by regulating mTOR/SREBP1 signaling pathway in obese mice]. Zhongguo Zhen Jiu. 2026;46:1482-1490. PMID: 42744635. MeSH: Signal Transduction
  4. Curtin MC, Jackson AE, Lee MD, Brown EA, Maschek JA, Lum DH, et al. Lean adipocyte oxylipin signaling restrains breast cancer through ferroptosis. Science. 2026;393:eaea4287. PMID: 42721252. MeSH: Signal Transduction
  5. Lim S, Evallo E, Kim DI, Park MJ. Adipocyte-specific MC2R overexpression exerts minimal metabolic effects in mice. Lab Anim Res. 2026;42:34. PMID: 42698109. keyword: Melanocortin 2 receptor
  6. Madhavan SR, Moore P, Ma Q, Atit RP. DPP4 Substrate Supplementation Protects From WNT-Induced Lipid Depletion in Dermal Adipocytes. Exp Dermatol. 2026;35:e70354. PMID: 42655870. MeSH: Wnt Signaling Pathway
  7. Zhu A, Zhou Y, Ren K, Sun C. IRF1 in Adipocytes Is Associated with Insulin Signaling and Mitochondrial Homeostasis in Diet-Induced Obesity. Int J Mol Sci. 2026;27:7332. PMID: 42653336. MeSH: Signal Transduction
  8. Wang F, Meng Q, Gao J, Cui T, Qi Z, Zhao N, et al. GPR35 Mediates the Proliferation and Adipogenesis of Goat Intramuscular Preadipocytes Through the cAMP/PKA Signaling Pathway. Animals (Basel). 2026;16:2560. PMID: 42651965. keyword: cAMP/PKA signaling pathway
  9. Di Fulvio M. The aryl hydrocarbon receptor as a tissue-specific modulator of insulin sensitivity: evidence from conditional deletion studies. Toxicol Sci. 2026;209:kfag103. PMID: 42635556. MeSH: Receptors, Aryl Hydrocarbon
  10. Zhang YR, Zhou ZY, Xia JN, Wang YF, Zhang ZY, Liao LL, et al. [Effect of electroacupuncture on hepatic autophagy in obese mice based on the AMPK/mTOR/ULK1 pathway]. Zhen Ci Yan Jiu. 2026;51:955-967. PMID: 42621706. MeSH: Signal Transduction
  11. He Y, Pan L, Ping W, Meng C, Meng X, Guo Y, et al. An ANGPTL8-AKT2-mTOR Axis Drives Adipose Senescence and Aging-Related Functional Decline. Aging Cell. 2026;25:e70671. PMID: 42605193. MeSH: Signal Transduction
  12. Kim S, Nguyen PA, Park KS, Cha SK, Namkung J. Orai1-mediated Ca2+ entry regulates lipolysis and mitochondrial activation in brown adipose thermogenesis. Exp Mol Med. 2026;58:2781-2791. PMID: 42595867. MeSH: Calcium Signaling
  13. Fu Z, Yang C, Huang Q, Pan Y, Wu H, Cai Y, et al. An N-salicyloyl tryptamine derivative (compound 18) improves spermatogenic impairment in obese mice via regulating insulin resistance and enhancing Sertoli cell glycolysis. Mol Cell Endocrinol. 2026;622:112894. PMID: 42595295. MeSH: Signal Transduction
  14. Füchtbauer LM, Senn JR, Baumann CS, Isenrich AL, Gaynor TL, Schläfli R, et al. Beta2-adrenergic stimulation by fenoterol increases energy expenditure without activating human brown adipose tissue. Cell Metab. 2026;38:1802-1814.e4. PMID: 42586060. MeSH: Receptors, Adrenergic, beta-2
  15. An SH, Park JY, Lee SJ. KPV attenuates adipogenesis and lipid metabolism through modulation of ROS-mediated AKT/mTORC1/PPARγ signaling. Tissue Cell. 2026;104:103837. PMID: 42585803. keyword: AKT/mTOR signaling
  16. Zhao Y, Wang F. Stigmasterol ameliorates obesity-associated insulin resistance by activating the PPARγ pathway and alleviating oxidative stress. Front Endocrinol (Lausanne). 2026;17:1888104. PMID: 42582192. MeSH: Signal Transduction
  17. Cai S, Ma M, Zhu Y, Shi M, Dai X, Wang Y, et al. Chemokine receptor CCR1 restrains adipose tissue remodelling via cAMP/PKA/CREB signalling and adipocyte‒macrophage crosstalk in mice. Clin Transl Med. 2026;16:e70762. PMID: 42557944. MeSH: Signal Transduction
  18. Chu Y, Zhang Y, Chu C, Liu Y, Tang J, Yu F, et al. Endothelial TRPV4 mitigates obesity-induced metabolic dysfunction via Ca2+-dependent eNOS phosphorylation. Int Immunopharmacol. 2026;187:117202. PMID: 42546516. MeSH: Signal Transduction
  19. Guerrero JJG, Del Rosario MAS, Encarnacion PC, Lin CS, Chuang LT, Notarte KI, et al. Adipose Tissue Browning in MASLD and Its Molecular Mechanisms and Metabolic Crosstalk. Curr Obes Rep. 2026;15:68. PMID: 42538483. MeSH: Signal Transduction
  20. Suryaningtyas IT, Jung WK, Je JY. Dieckol suppresses lipid accumulation and promotes thermogenic markers in 3T3-L1 adipocytes via ERK/p38 MAPK signaling. J Physiol Biochem. 2026;82:75. PMID: 42530711. MeSH: MAP Kinase Signaling System
  21. Hu X, Wu D, Jia F, Zhu S, Ke S, Chen D, et al. Adipocyte-derived LTB4 programs human NKG2A+ γδ T cells as cytotoxic sentinels at the adipose-tumor interface in breast cancer. J Immunother Cancer. 2026;14:e015147. PMID: 42521410. MeSH: Receptors, Antigen, T-Cell, gamma-delta
  22. Sehra A, Tsiani E. Chlorogenic Acid as a Modulator of Adipose Tissue Function and Metabolic Homeostasis: Evidence from Preclinical Studies. Nutrients. 2026;18:2358. PMID: 42514427. keyword: insulin signaling
  23. Fu M, Singh MK, Kim G, Yoon KS, Kim SS, Ha J, et al. 2-O-Methylhonokiol Suppresses 3T3-L1 Adipogenesis Through Metabolic Stress Signaling and Early Cell Cycle Restriction. Int J Mol Sci. 2026;27:6529. PMID: 42511869. MeSH: Signal Transduction
  24. Perumal NL, Hussain M, Son DG, Stephens JM, Park GY, Jang BC. BIX02189 Suppresses Adipogenesis and Lipid Accumulation Through Inhibition of MEK5-STAT3/STAT5 Signaling and Activation of AMPK in Adipocytes and Zebrafish. Int J Mol Sci. 2026;27:6468. PMID: 42511811. MeSH: Signal Transduction
  25. Popescu MR, Panaitescu AM, Ceafalan LC, Hinescu ME. CD36 as a Context-Dependent Regulator of Metabolic Switching in Acute and Chronic Hypoxia. Biomolecules. 2026;16:1018. PMID: 42509811. MeSH: Signal Transduction
  26. Yoon NG, Kim SY, Jung SY, Kwon K, Yeom SA, Park HK, et al. The pro-tumorigenic functions of cancer-associated adipocytes are dependent on the mitochondrial chaperone tumor necrosis factor receptor-associated protein 1. Signal Transduct Target Ther. 2026;11:294. PMID: 42509229. MeSH: Signal Transduction

Medications 36

Filed by MeSH heading or keyword; each paper says which one matched. The Medications page holds the dated feed.

  1. Li J, Gao W, Yuan X, Li H, Sun J, Ji H. Inducing adipocyte hyperplasia improves growth performance, alleviates hepatic steatosis and counteracts muscle quality deterioration in largemouth bass (Micropterus salmoides) fed with high-carbohydrate diet. Fish Physiol Biochem. 2026;52:173. PMID: 42782380. MeSH: Adipocytes/drug effects
  2. Uti DE, Alum EU, Egbung JE, Mohammedsaleh ZM, Kaur M, Ealla KKR. Metabolic Reprogramming of Cancer Stem Cells: Targeting Lipid Flux and Mitochondrial Plasticity to Overcome Therapeutic Resistance. Cancer Med. 2026;15:e72275. PMID: 42760790. MeSH: Neoplastic Stem Cells/drug effects
  3. So S, Kwon S, Choi Y, Kim DY, Kim MH. High‑fat diet exacerbates hepatic and adipose insulin signaling impairment and ovarian lesions in a rat model of letrozole‑induced polycystic ovary syndrome. Mol Med Rep. 2026;34:308. PMID: 42757461. MeSH: Signal Transduction/drug effects
  4. Zhang J, Shou Y, Tang Y, Du X, Chen J, Peng H, et al. AMPK/Autophagy-Dependent Pro-Adipogenic Effect Coupled With Enhanced Lipid Mobilization and Thermogenesis Underlies the Dual Action of Canagliflozin Against Obesity. FASEB J. 2026;40:e72313. PMID: 42752874. MeSH: Thermogenesis/drug effects
  5. Matsunaga Y, Inoue MK, Kanna M, Asano T, Nakatsu Y. The Effect of Prolyl Isomerase Pin1 on the Development of Metabolic Dysfunction-Associated Steatohepatitis and a New Treatment Strategy. Int J Mol Sci. 2026;27:7788. PMID: 42737685. MeSH: NIMA-Interacting Peptidylprolyl Isomerase/antagonists & inhibitors
  6. Sato T, Fujii A, Kato S, Afiyanti M, Shirako S, Nishidono Y, et al. Hydrophobic Compounds in the Paeonia suffruticosa Root Cortex Reduce Lipid Accumulation in Adipocytes and the Livers of Obese ob/ob Mice. Biol Pharm Bull. 2026;49:1471-1481. PMID: 42716794. MeSH: Adipocytes/drug effects
  7. Castañé H, Spangenberger C, de Souza IR, Kristoforus T, Lazarevski L, Yim J, et al. Adipose tissue-on-Chip platforms for disease modelling, drug discovery and pharmacokinetic modelling. Adv Drug Deliv Rev. 2026:115971. PMID: 42705345. keyword: Tissue-specific drug targeting
  8. Mehboodi M, Khodayar A, Namavar N, Ziaee Ghochan Atigh T, Zeynali T, Hossein Mardi F, et al. Bifidobacterium adolescentis attenuates brown adipose tissue whitening and improves metabolic markers in high-fat diet-induced obese rats. Daru. 2026;34:71. PMID: 42702700. MeSH: Adipose Tissue, Brown/drug effects
  9. Tu S, Wang X, Wang Z, Tang H, Yin K, Zhu X. Licoisoflavone A ameliorates adipose tissue dysfunction in diet‑induced obesity by promoting METTL3 expression. Mol Med Rep. 2026;34:296. PMID: 42695398. MeSH: Obesity/drug therapy
  10. Frendo-Cumbo S, Zareifi D, Bigay J, Dias Araújo AR, Lapp A, Hansen M, et al. Functional annotation of insulin-responsive genes in human adipocytes reveals PLCXD1 as a lipid storage regulator. Nat Commun. 2026;17:9458. PMID: 42693141. MeSH: Adipocytes/drug effects
  11. Ghesmati Z, Rashid M, Fayezi S, Alizadeh E, Darabi M. Brown and white adipocyte like cells derived exosomes differentially regulate stemness, hormone secretion, apoptosis, and lipid metabolism in model cells. PLoS One. 2026;21:e0355955. PMID: 42678968. MeSH: Apoptosis/drug effects
  12. Madhavan SR, Moore P, Ma Q, Atit RP. DPP4 Substrate Supplementation Protects From WNT-Induced Lipid Depletion in Dermal Adipocytes. Exp Dermatol. 2026;35:e70354. PMID: 42655870. MeSH: Adipocytes/drug effects
  13. Tsonov MN, Gish PE, Vahmani P. Effects of linoleic acid and its trans-10 biohydrogenation intermediates (trans-10, cis-12 conjugated linoleic acid and trans-10 18:1) on lipogenic gene expression and Δ9-desaturation indices in bovine intramuscular adipocytes. J Anim Sci. 2026;104:skag268. PMID: 42647272. MeSH: Adipocytes/drug effects
  14. Gunsch G, Mishra G, Blaszkiewicz M, de Sousa E, Willows JW, Alltop KW, et al. Effects of 6-OHDA-Mediated Chemical Denervation of Sympathetic Axons in Inguinal Subcutaneous White Adipose Tissue. Diabetes Obes Metab. 2026;28:10459-10474. PMID: 42642346. MeSH: Oxidopamine/pharmacology
  15. Jiang X, Avellino A, Yu J, Liu S, Zhao L, Wang Z, et al. Targeting circulating fatty acid-binding protein 4 ameliorates obesity-associated hepatic steatosis. JHEP Rep. 2026;8:101999. PMID: 42624369. keyword: Immunotherapy
  16. Dos Santos FCF, Eskridge KR, Laws MJ, Flaws JA, Graceli JB. Effects of phthalates on mammalian adipose tissue. Toxicol Sci. 2026;209:kfag111. PMID: 42623126. MeSH: Adipose Tissue, White/drug effects
  17. Kang BM, Choi HS, Kim BR, Youn SW, Kwon HJ, Lee JK, et al. Inhibition of fatty acid-binding protein 4 alleviates psoriasis-like skin inflammation by modulating macrophage polarization. Front Immunol. 2026;17:1830077. PMID: 42609463. MeSH: Psoriasis/drug therapy
  18. Fu Z, Yang C, Huang Q, Pan Y, Wu H, Cai Y, et al. An N-salicyloyl tryptamine derivative (compound 18) improves spermatogenic impairment in obese mice via regulating insulin resistance and enhancing Sertoli cell glycolysis. Mol Cell Endocrinol. 2026;622:112894. PMID: 42595295. MeSH: Sertoli Cells/drug effects
  19. Ye HL, Wang YN, Li GA, Jin XH, Li Y, Jin YH. A novel continuous-progression CKM model combined with multi-omics data integration identifies lipid metabolic drivers of disease progression. Front Endocrinol (Lausanne). 2026;17:1910505. PMID: 42591226. keyword: virtual drug screening
  20. García-Dávila S, Cifuentes C, Gracia I, Gómez LA, Llorens S. Effect of Combined Grape Seed (Vitis vinifera) and Garlic (Allium sativum) Extracts on Adipogenesis in the 3T3-L1 Preadipocyte Line. Int J Mol Sci. 2026;27:7043. PMID: 42589693. MeSH: Adipogenesis/drug effects
  21. Füchtbauer LM, Senn JR, Baumann CS, Isenrich AL, Gaynor TL, Schläfli R, et al. Beta2-adrenergic stimulation by fenoterol increases energy expenditure without activating human brown adipose tissue. Cell Metab. 2026;38:1802-1814.e4. PMID: 42586060. MeSH: Adipose Tissue, Brown/drug effects
  22. Kleißen J, Goerdeler C, Aldehoff AS, Karkossa I, Didio A, Schmidt J, et al. Halogenated bisphenol A alternatives inhibit aldo-keto reductase 1C1 and induce metabolic alterations in human adipocytes. J Hazard Mater. 2026;515:143238. PMID: 42585961. MeSH: Adipocytes/drug effects
  23. Zhao Y, Wang F. Stigmasterol ameliorates obesity-associated insulin resistance by activating the PPARγ pathway and alleviating oxidative stress. Front Endocrinol (Lausanne). 2026;17:1888104. PMID: 42582192. MeSH: Oxidative Stress/drug effects
  24. Cai S, Ma M, Zhu Y, Shi M, Dai X, Wang Y, et al. Chemokine receptor CCR1 restrains adipose tissue remodelling via cAMP/PKA/CREB signalling and adipocyte‒macrophage crosstalk in mice. Clin Transl Med. 2026;16:e70762. PMID: 42557944. MeSH: Signal Transduction/drug effects
  25. Xu JQ, Cai ZW, Pang ZY, Chen WJ, Chen JY, Wang DJ, et al. [Mechanism of total flavonoids from Smilacis Glabrae Rhizoma against obesity-associated colorectal cancer via regulation of fatty acid oxidation]. Zhongguo Zhong Yao Za Zhi. 2026;51:3818-3829. PMID: 42543372. MeSH: Colorectal Neoplasms/drug therapy
  26. Uslu M, Biçer O, Önaloğlu Y, Balcı E, Güleryüz Y, Acar A, et al. Dose-dependent protective effects of punicalagin on steroid-induced osteonecrosis in a rat model. Jt Dis Relat Surg. 2026;37:785-799. PMID: 42542923. MeSH: Hydrolyzable Tannins/pharmacology
  27. Suryaningtyas IT, Jung WK, Je JY. Dieckol suppresses lipid accumulation and promotes thermogenic markers in 3T3-L1 adipocytes via ERK/p38 MAPK signaling. J Physiol Biochem. 2026;82:75. PMID: 42530711. MeSH: p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
  28. Bao C, Chen X, Fu J, Tang T, Zhang L, Li L, et al. A Novel Microfluidic Strategy for the Fabrication of α-Lactalbumin Nanomicelles Paves a New Path for Antiobesity Technology. Adv Healthc Mater. 2026;15:e71486. PMID: 42516046. MeSH: Obesity/drug therapy
  29. Sehra A, Tsiani E. Chlorogenic Acid as a Modulator of Adipose Tissue Function and Metabolic Homeostasis: Evidence from Preclinical Studies. Nutrients. 2026;18:2358. PMID: 42514427. MeSH: Chlorogenic Acid/pharmacology
  30. Figueroa-Guzmán C, Campos-Morales ME, Martínez-Alcantar L, Hernández-Padilla L, Sánchez-Duarte E, Sánchez-Briones LA, et al. Cyclodipeptides Reversed Liver Damage and Adipose Tissue Dysfunction in a Chronic Obesity MASLD Rat Model by Remodeling White Adipocytes Toward a Beige-like Adipocyte Phenotype. Molecules. 2026;31:2466. PMID: 42513149. MeSH: Obesity/drug therapy
  31. Fu M, Singh MK, Kim G, Yoon KS, Kim SS, Ha J, et al. 2-O-Methylhonokiol Suppresses 3T3-L1 Adipogenesis Through Metabolic Stress Signaling and Early Cell Cycle Restriction. Int J Mol Sci. 2026;27:6529. PMID: 42511869. MeSH: Adipogenesis/drug effects
  32. Perumal NL, Hussain M, Son DG, Stephens JM, Park GY, Jang BC. BIX02189 Suppresses Adipogenesis and Lipid Accumulation Through Inhibition of MEK5-STAT3/STAT5 Signaling and Activation of AMPK in Adipocytes and Zebrafish. Int J Mol Sci. 2026;27:6468. PMID: 42511811. MeSH: Adipogenesis/drug effects
  33. Cavalcanti MH, Damazo AS, Arruda SF. Tucum-do-Cerrado (Bactris setosa Mart.) Consumption Promoted a Healthier Expansion of Adipose Tissue in High-Fat Diet-Induced Obesity Rats. Mol Nutr Food Res. 2026;70:e70498. PMID: 42377995. MeSH: Adipose Tissue/drug effects
  34. Zhao Q, Xie L, Wang Q, Dai S, Li B, Zhang Y, et al. Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness. Adv Sci (Weinh). 2026;13:e16501. PMID: 42299748. MeSH: Thermogenesis/drug effects
  35. Bi Y, Zhang G, Wang Y, Zhang L, Wu S, Zhang Y, et al. Cordycepin Ameliorates Constant Light-Induced Thermogenic Dysfunction in Brown Adipose Tissue by Activating SIRT1-Mediated Mitochondrial Homeostasis. Int J Mol Sci. 2026;27:4351. PMID: 42196331. MeSH: Adipose Tissue, Brown/drug effects
  36. Ma D, Wu T, Qu Y, Yang J, Cai L, Li X, et al. Astragalus polysaccharide prevents heart failure-induced cachexia by alleviating excessive adipose expenditure in white and brown adipose tissue. Lipids Health Dis. 2023;22:9. PMID: 36670439. MeSH: Cachexia/drug therapy

Disorders 49

Filed by MeSH heading or keyword; each paper says which one matched. The Disorders page holds the dated feed.

  1. Li Z, Zhao P, Yang W, Zhou J, Liu H. Selenoprotein F gates diet-induced female-specific obesity via adipose IRE1α-mediated endoplasmic reticulum stress. Biochim Biophys Acta Mol Basis Dis. 2027;1873:168411. PMID: 42586509. MeSH: Obesity/pathology
  2. Aboud G, Benson TW, Harb R, Veerapaneni P, Zhang G, Ahmadieh S, et al. Hematopoietic-Specific DARC Deficiency Is Associated with Adipose Tissue Inflammation and Impaired Glucose Tolerance During Diet-Induced Obesity in Mice. Cells. 2026;15:1664. PMID: 42782763. MeSH: Obesity/pathology
  3. Li J, Gao W, Yuan X, Li H, Sun J, Ji H. Inducing adipocyte hyperplasia improves growth performance, alleviates hepatic steatosis and counteracts muscle quality deterioration in largemouth bass (Micropterus salmoides) fed with high-carbohydrate diet. Fish Physiol Biochem. 2026;52:173. PMID: 42782380. MeSH: Adipocytes/pathology
  4. Uti DE, Alum EU, Egbung JE, Mohammedsaleh ZM, Kaur M, Ealla KKR. Metabolic Reprogramming of Cancer Stem Cells: Targeting Lipid Flux and Mitochondrial Plasticity to Overcome Therapeutic Resistance. Cancer Med. 2026;15:e72275. PMID: 42760790. MeSH: Neoplastic Stem Cells
  5. So S, Kwon S, Choi Y, Kim DY, Kim MH. High‑fat diet exacerbates hepatic and adipose insulin signaling impairment and ovarian lesions in a rat model of letrozole‑induced polycystic ovary syndrome. Mol Med Rep. 2026;34:308. PMID: 42757461. MeSH: Polycystic Ovary Syndrome
  6. Matsunaga Y, Inoue MK, Kanna M, Asano T, Nakatsu Y. The Effect of Prolyl Isomerase Pin1 on the Development of Metabolic Dysfunction-Associated Steatohepatitis and a New Treatment Strategy. Int J Mol Sci. 2026;27:7788. PMID: 42737685. MeSH: Fatty Liver/etiology
  7. Curtin MC, Jackson AE, Lee MD, Brown EA, Maschek JA, Lum DH, et al. Lean adipocyte oxylipin signaling restrains breast cancer through ferroptosis. Science. 2026;393:eaea4287. PMID: 42721252. MeSH: Breast Neoplasms
  8. Mintz RL, Han J, Butka EG, Gallerand A, Gao S, Kim A, et al. Peritoneal ovarian cancer growth in the omentum proceeds independently of mature adipocytes. Nat Commun. 2026;17:9673. PMID: 42716945. MeSH: Omentum/pathology
  9. Caballero CD, Schulze A. Dangerous liaisons: interactions between cancer cells and adipocytes as drivers of cancer progression. Genes Dev. 2026;40:1598-1613. PMID: 42716718. MeSH: Adipocytes/pathology
  10. Mehboodi M, Khodayar A, Namavar N, Ziaee Ghochan Atigh T, Zeynali T, Hossein Mardi F, et al. Bifidobacterium adolescentis attenuates brown adipose tissue whitening and improves metabolic markers in high-fat diet-induced obese rats. Daru. 2026;34:71. PMID: 42702700. MeSH: Adipose Tissue, Brown/pathology
  11. Tu S, Wang X, Wang Z, Tang H, Yin K, Zhu X. Licoisoflavone A ameliorates adipose tissue dysfunction in diet‑induced obesity by promoting METTL3 expression. Mol Med Rep. 2026;34:296. PMID: 42695398. MeSH: Obesity/etiology
  12. Corvera S, Czech MP. Energy's long game: thermogenic adipocytes and the metabolic diseases of modern life. Acad Biol. 2026;4. PMID: 42694970. keyword: cardiometabolic disease
  13. Sato S. Current and Future Perspectives on Adipo-Oncology: Roles of Adipocytes in Local and Systemic Tumor Regulation. Pathol Int. 2026;76:e70170. PMID: 42693631. MeSH: Adipocytes/pathology
  14. Zhu A, Zhou Y, Ren K, Sun C. IRF1 in Adipocytes Is Associated with Insulin Signaling and Mitochondrial Homeostasis in Diet-Induced Obesity. Int J Mol Sci. 2026;27:7332. PMID: 42653336. MeSH: Obesity/etiology
  15. Mikhaleva L, Martynova M, Gioeva Z, Shakhpazyan N, Chizhikov N, Pechnikova V, et al. SARIFA and Lipid Metabolic Reprogramming in Prostate Cancer: Fundamental Mechanisms, Tumor Microenvironment, and Novel Biomarker Prospects. Life (Basel). 2026;16:1304. PMID: 42652992. keyword: prostate cancer
  16. Ylikomi T, Nees M. Ketogenic Diet as an Adjuvant in Epithelial Cancers: Mechanisms, Model Systems, and Translational Opportunities. Cancers (Basel). 2026;18:2600. PMID: 42649914. keyword: epithelial cancer
  17. Shi J, Abdel-Ghany S, Abdel-Fattah M, Hu X, Wadan AS, Sabit H. Cancer-associated adipocytes: metabolic reprogramming, crosstalk and therapeutic implications in tumor progression. Signal Transduct Target Ther. 2026;11:347. PMID: 42637735. MeSH: Adipocytes/pathology
  18. Di Fulvio M. The aryl hydrocarbon receptor as a tissue-specific modulator of insulin sensitivity: evidence from conditional deletion studies. Toxicol Sci. 2026;209:kfag103. PMID: 42635556. keyword: metabolic syndrome
  19. Brown RDR, Weigel C, Vijayan Y, Tyc KM, Carter C, Green CD, et al. Sphingosine kinase 2 regulates adipocyte browning and whole-body metabolism. Sci Adv. 2026;12:eaec7066. PMID: 42627910. MeSH: Obesity/etiology
  20. Li A, Yue B, Hu H, Li X, Li Z, Ma Y, et al. Adipose-specific Kdm2a deficiency promotes ferroptosis-associated features and hypertrophic remodeling of adipocytes. J Lipid Res. 2026;67:101127. PMID: 42624370. MeSH: Adipocytes/pathology
  21. Dos Santos FCF, Eskridge KR, Laws MJ, Flaws JA, Graceli JB. Effects of phthalates on mammalian adipose tissue. Toxicol Sci. 2026;209:kfag111. PMID: 42623126. MeSH: Adipose Tissue, White/pathology
  22. Zhang YR, Zhou ZY, Xia JN, Wang YF, Zhang ZY, Liao LL, et al. [Effect of electroacupuncture on hepatic autophagy in obese mice based on the AMPK/mTOR/ULK1 pathway]. Zhen Ci Yan Jiu. 2026;51:955-967. PMID: 42621706. MeSH: Obesity/physiopathology
  23. Kang BM, Choi HS, Kim BR, Youn SW, Kwon HJ, Lee JK, et al. Inhibition of fatty acid-binding protein 4 alleviates psoriasis-like skin inflammation by modulating macrophage polarization. Front Immunol. 2026;17:1830077. PMID: 42609463. MeSH: Psoriasis/pathology
  24. Ma YX, Lin M, Nan Y, Li NN, Liu B, Wang HR, et al. Obesity-driven low-grade chronic inflammation as a mechanistic bridge to chronic pain: from adipose tissue remodeling to central sensitization. Front Immunol. 2026;17:1889437. PMID: 42597587. MeSH: Chronic Pain/etiology
  25. Fu Z, Yang C, Huang Q, Pan Y, Wu H, Cai Y, et al. An N-salicyloyl tryptamine derivative (compound 18) improves spermatogenic impairment in obese mice via regulating insulin resistance and enhancing Sertoli cell glycolysis. Mol Cell Endocrinol. 2026;622:112894. PMID: 42595295. MeSH: Sertoli Cells/pathology
  26. Ye HL, Wang YN, Li GA, Jin XH, Li Y, Jin YH. A novel continuous-progression CKM model combined with multi-omics data integration identifies lipid metabolic drivers of disease progression. Front Endocrinol (Lausanne). 2026;17:1910505. PMID: 42591226. MeSH: Disease Progression
  27. Chávez-Ortega MP, Peña-Peña M, Carbó R, Medina-Urrutia A, Osorio-Alonso H, Jiang B, et al. Adipose Tissue Heterogeneity: Depot-Specific Location and Functional Specialization in Obesity-Related Disease. Int J Mol Sci. 2026;27:6693. PMID: 42589349. MeSH: Obesity/pathology
  28. Pampaloni F, Piraccini BM, Bruni F, Quadrelli F, Misciali C, Merlini L, et al. Hair Follicle Microenvironment Changes in Collagen VI-Myopathy Patients with Alopecia. Cells. 2026;15:1351. PMID: 42587761. MeSH: Alopecia/pathology
  29. Sasankan D, Mohan R. The Mechanobiology of Adipocyte Hypertrophy: Cytoskeletal Remodelling as a Driver of Insulin Resistance in Obesity. Cell Biochem Funct. 2026;44:e70283. PMID: 42583807. MeSH: Adipocytes/pathology
  30. Wang HR, Lv XH, Sun Y, Gu ZC, Lin M, Guan L, et al. Extracellular vesicle-mediated immune-metabolic crosstalk: research advances in inflammatory regulation and the pathogenesis of metabolic diseases. Front Immunol. 2026;17:1884606. PMID: 42583072. MeSH: Inflammation
  31. Zhao Y, Wang F. Stigmasterol ameliorates obesity-associated insulin resistance by activating the PPARγ pathway and alleviating oxidative stress. Front Endocrinol (Lausanne). 2026;17:1888104. PMID: 42582192. MeSH: Obesity/pathology
  32. Divoux A, Erdos E, Whytock KL, Osborne TF, Smith SR. Impaired adipogenesis and lipid storage capacity in subcutaneous adipose tissue of patients with PMOS. JCI Insight. 2026;11:e199981. PMID: 42579798. MeSH: Subcutaneous Fat/pathology
  33. Yan Y, Chen L. Organelle contact sites as spatial regulators of lipid fate in adipose tissue metabolic disease. Life Sci. 2026;403:124624. PMID: 42567497. keyword: Metabolic disease
  34. Liu P, Long K, Wang Y, Sulaiman JE, Wang B, Zhou X, et al. MDM2 deletion and its associated p53 activation in subcutaneous white adipose tissue induce hepatic fibrosis via galectin-3 in a mouse model. Metabolism. 2026;184:156726. PMID: 42567474. MeSH: Liver Cirrhosis/pathology
  35. Chu Y, Zhang Y, Chu C, Liu Y, Tang J, Yu F, et al. Endothelial TRPV4 mitigates obesity-induced metabolic dysfunction via Ca2+-dependent eNOS phosphorylation. Int Immunopharmacol. 2026;187:117202. PMID: 42546516. keyword: Inflammation
  36. Sebestyén A, Varga V, Szalai F, Miyaura R, Förhécz N, Csikós B, et al. CD36-mediated lipid rewiring in the metabolic adaptation of tumour ecosystems. FEBS J. 2026. PMID: 42543461. keyword: cancer
  37. Xu JQ, Cai ZW, Pang ZY, Chen WJ, Chen JY, Wang DJ, et al. [Mechanism of total flavonoids from Smilacis Glabrae Rhizoma against obesity-associated colorectal cancer via regulation of fatty acid oxidation]. Zhongguo Zhong Yao Za Zhi. 2026;51:3818-3829. PMID: 42543372. MeSH: Colorectal Neoplasms
  38. Uslu M, Biçer O, Önaloğlu Y, Balcı E, Güleryüz Y, Acar A, et al. Dose-dependent protective effects of punicalagin on steroid-induced osteonecrosis in a rat model. Jt Dis Relat Surg. 2026;37:785-799. PMID: 42542923. MeSH: Disease Models, Animal
  39. Guerrero JJG, Del Rosario MAS, Encarnacion PC, Lin CS, Chuang LT, Notarte KI, et al. Adipose Tissue Browning in MASLD and Its Molecular Mechanisms and Metabolic Crosstalk. Curr Obes Rep. 2026;15:68. PMID: 42538483. MeSH: Fatty Liver/physiopathology
  40. Wilde BR, Klingbeil KD, Day F, Dann C, Frias C, Nakasaki M, et al. PPARG governs adipogenic differentiation and cell state plasticity in well-differentiated and dedifferentiated liposarcoma. Sci Adv. 2026;12:eaea6516. PMID: 42536718. MeSH: Liposarcoma/pathology
  41. Hu X, Wu D, Jia F, Zhu S, Ke S, Chen D, et al. Adipocyte-derived LTB4 programs human NKG2A+ γδ T cells as cytotoxic sentinels at the adipose-tumor interface in breast cancer. J Immunother Cancer. 2026;14:e015147. PMID: 42521410. MeSH: Breast Neoplasms
  42. Figueroa-Guzmán C, Campos-Morales ME, Martínez-Alcantar L, Hernández-Padilla L, Sánchez-Duarte E, Sánchez-Briones LA, et al. Cyclodipeptides Reversed Liver Damage and Adipose Tissue Dysfunction in a Chronic Obesity MASLD Rat Model by Remodeling White Adipocytes Toward a Beige-like Adipocyte Phenotype. Molecules. 2026;31:2466. PMID: 42513149. MeSH: Obesity/pathology
  43. Yan M, Wang H, Sha W, Fu Y. UCP1-Dependent Thermogenic Adipose Tissue in Human Disease: Adipose-Centered Mechanisms, Biomarker Limitations, and Translational Perspectives. Int J Mol Sci. 2026;27:6416. PMID: 42511758. keyword: cancer metabolism
  44. Popescu MR, Panaitescu AM, Ceafalan LC, Hinescu ME. CD36 as a Context-Dependent Regulator of Metabolic Switching in Acute and Chronic Hypoxia. Biomolecules. 2026;16:1018. PMID: 42509811. MeSH: Inflammation
  45. Yoon NG, Kim SY, Jung SY, Kwon K, Yeom SA, Park HK, et al. The pro-tumorigenic functions of cancer-associated adipocytes are dependent on the mitochondrial chaperone tumor necrosis factor receptor-associated protein 1. Signal Transduct Target Ther. 2026;11:294. PMID: 42509229. MeSH: Mitochondria/pathology
  46. Neuhaus M, Fryklund C, Cai M, Fernø J, Mellgren G, Hagberg CE, et al. Depot-specific differences in visceral and subcutaneous adipose tissue from patients with obesity. Adipocyte. 2026;15:2708374. PMID: 42504078. MeSH: Obesity/pathology
  47. Cavalcanti MH, Damazo AS, Arruda SF. Tucum-do-Cerrado (Bactris setosa Mart.) Consumption Promoted a Healthier Expansion of Adipose Tissue in High-Fat Diet-Induced Obesity Rats. Mol Nutr Food Res. 2026;70:e70498. PMID: 42377995. MeSH: Obesity/etiology
  48. Valdivieso-Rivera F, Furino VO, Leher CE, Zanesco AM, Cruz MK, Gan FC, et al. E4BP4 safeguards brown fat mitochondria from obesity-induced fragmentation via ceramide repression. EMBO Rep. 2026;27:4376-4411. PMID: 42332066. MeSH: Obesity/pathology
  49. Ma D, Wu T, Qu Y, Yang J, Cai L, Li X, et al. Astragalus polysaccharide prevents heart failure-induced cachexia by alleviating excessive adipose expenditure in white and brown adipose tissue. Lipids Health Dis. 2023;22:9. PMID: 36670439. MeSH: Cachexia/etiology

Publications 114

Filed by MeSH heading or keyword; each paper says which one matched. The Publications page holds the dated feed.

  1. Li Z, Zhao P, Yang W, Zhou J, Liu H. Selenoprotein F gates diet-induced female-specific obesity via adipose IRE1α-mediated endoplasmic reticulum stress. Biochim Biophys Acta Mol Basis Dis. 2027;1873:168411. PMID: 42586509. research paper
  2. Xiao J, Li S, Jiang Z, Liu M, Tang J. IGF2BP3 suppresses adipogenesis via m6A-dependent stabilization of FAM13A mRNA in 3T3-L1 adipocytes. Mol Cell Endocrinol. 2026;623:112928. PMID: 42785510. research paper
  3. Aboud G, Benson TW, Harb R, Veerapaneni P, Zhang G, Ahmadieh S, et al. Hematopoietic-Specific DARC Deficiency Is Associated with Adipose Tissue Inflammation and Impaired Glucose Tolerance During Diet-Induced Obesity in Mice. Cells. 2026;15:1664. PMID: 42782763. research paper
  4. Yang S, Mu L, He X, Wang W, Zhang H, Tian M, et al. Effects of Cold Stress on the Morphology and Thermogenic Capacity of Adipose Tissue in Various Anatomical Depots of Min pigs. Cells. 2026;15:1661. PMID: 42782761. research paper
  5. Li J, Gao W, Yuan X, Li H, Sun J, Ji H. Inducing adipocyte hyperplasia improves growth performance, alleviates hepatic steatosis and counteracts muscle quality deterioration in largemouth bass (Micropterus salmoides) fed with high-carbohydrate diet. Fish Physiol Biochem. 2026;52:173. PMID: 42782380. research paper
  6. Bernier KJ, Gao Z, Bhatia Y, Dehkordi NB, Nasiri F, Daquinag AC, et al. Prohibitin-1 cysteine-69 plays a sex-dependent role in fatty acid metabolism. J Lipid Res. 2026:101158. PMID: 42778065. research paper
  7. Farinacci G, Palmisano B. Not just fillers: the emerging role of bone marrow adipocytes in bone and bone marrow homeostasis. Biol Open. 2026;15:bio062461. PMID: 42770526. research paper
  8. Malhi R, Wong M, Qudratullah V, Gondal D, Tinkov AA, Skalny AV, et al. Persistent effects of pre-differentiation manganese exposure on adipogenesis and metabolic function in differentiated 3T3-L1 adipocyte cells. J Hazard Mater Adv. 2026;23:101506. PMID: 42769861. research paper
  9. Uti DE, Alum EU, Egbung JE, Mohammedsaleh ZM, Kaur M, Ealla KKR. Metabolic Reprogramming of Cancer Stem Cells: Targeting Lipid Flux and Mitochondrial Plasticity to Overcome Therapeutic Resistance. Cancer Med. 2026;15:e72275. PMID: 42760790. research paper
  10. Li X, Liu Y, Wang F, Zhang F, Zhang L, Dang Y, et al. Liraglutide Ameliorates Atrial Fibrillation in Association with Enhanced Adiponectin Signaling in Epicardial Adipose Tissue. Cardiovasc Drugs Ther. 2026. PMID: 42758273. research paper
  11. So S, Kwon S, Choi Y, Kim DY, Kim MH. High‑fat diet exacerbates hepatic and adipose insulin signaling impairment and ovarian lesions in a rat model of letrozole‑induced polycystic ovary syndrome. Mol Med Rep. 2026;34:308. PMID: 42757461. research paper
  12. Luo Y, Zhang Y, Song Y, Li X, Liang J, Xing H, et al. Brown adipocyte Acss1 restoration ameliorates redox-metabolic dysfunction and systemic metabolic decline during aging. Free Radic Biol Med. 2026;256:561-578. PMID: 42754181. research paper
  13. Picoli CC, Gilio GR, Henriques F, Santos KBNH, Lopes MA, de Moraes SMF, et al. A combination of aerobic and resistance training induces white adipose tissue browning. J Physiol Biochem. 2026;82:95. PMID: 42753033. research paper
  14. Zhang J, Shou Y, Tang Y, Du X, Chen J, Peng H, et al. AMPK/Autophagy-Dependent Pro-Adipogenic Effect Coupled With Enhanced Lipid Mobilization and Thermogenesis Underlies the Dual Action of Canagliflozin Against Obesity. FASEB J. 2026;40:e72313. PMID: 42752874. research paper
  15. Zhang Y, Huang W, Zhang Y, Xia J, Wang Y, Zhang Z, et al. [Electroacupuncture promotes browning of white adipose tissue by regulating mTOR/SREBP1 signaling pathway in obese mice]. Zhongguo Zhen Jiu. 2026;46:1482-1490. PMID: 42744635. research paper
  16. Li Z, Sun H, Wei Q, Li Y, Chen L, Lu L, et al. Functional characterization of lncIMF_17214 in regulating intramuscular fat deposition of yellow-feathered broilers. Poult Sci. 2026;105:107763. PMID: 42743734. research paper
  17. Matsunaga Y, Inoue MK, Kanna M, Asano T, Nakatsu Y. The Effect of Prolyl Isomerase Pin1 on the Development of Metabolic Dysfunction-Associated Steatohepatitis and a New Treatment Strategy. Int J Mol Sci. 2026;27:7788. PMID: 42737685. research paper
  18. Curtin MC, Jackson AE, Lee MD, Brown EA, Maschek JA, Lum DH, et al. Lean adipocyte oxylipin signaling restrains breast cancer through ferroptosis. Science. 2026;393:eaea4287. PMID: 42721252. research paper
  19. Mintz RL, Han J, Butka EG, Gallerand A, Gao S, Kim A, et al. Peritoneal ovarian cancer growth in the omentum proceeds independently of mature adipocytes. Nat Commun. 2026;17:9673. PMID: 42716945. research paper
  20. Sato T, Fujii A, Kato S, Afiyanti M, Shirako S, Nishidono Y, et al. Hydrophobic Compounds in the Paeonia suffruticosa Root Cortex Reduce Lipid Accumulation in Adipocytes and the Livers of Obese ob/ob Mice. Biol Pharm Bull. 2026;49:1471-1481. PMID: 42716794. research paper
  21. Caballero CD, Schulze A. Dangerous liaisons: interactions between cancer cells and adipocytes as drivers of cancer progression. Genes Dev. 2026;40:1598-1613. PMID: 42716718. research paper
  22. Miniewska K, Mojsak P, Chmielewska S, Choinska P, Godzien J, Labieniec L, et al. Activation of human brown adipocytes alters the plasma fatty acid profile. Front Mol Biosci. 2026;13:1842960. PMID: 42713526. research paper
  23. Castañé H, Spangenberger C, de Souza IR, Kristoforus T, Lazarevski L, Yim J, et al. Adipose tissue-on-Chip platforms for disease modelling, drug discovery and pharmacokinetic modelling. Adv Drug Deliv Rev. 2026:115971. PMID: 42705345. research paper
  24. Mehboodi M, Khodayar A, Namavar N, Ziaee Ghochan Atigh T, Zeynali T, Hossein Mardi F, et al. Bifidobacterium adolescentis attenuates brown adipose tissue whitening and improves metabolic markers in high-fat diet-induced obese rats. Daru. 2026;34:71. PMID: 42702700. research paper
  25. Guo Y, Jiao J, Zheng X. Long non-coding RNA GAS5 binds to miR-137 and regulates Nrf2 to ameliorate insulin resistance in adipose tissue in gestational diabetes mellitus. Diabet Med. 2026;43:e70451. PMID: 42698187. research paper
  26. Lim S, Evallo E, Kim DI, Park MJ. Adipocyte-specific MC2R overexpression exerts minimal metabolic effects in mice. Lab Anim Res. 2026;42:34. PMID: 42698109. research paper
  27. Tu S, Wang X, Wang Z, Tang H, Yin K, Zhu X. Licoisoflavone A ameliorates adipose tissue dysfunction in diet‑induced obesity by promoting METTL3 expression. Mol Med Rep. 2026;34:296. PMID: 42695398. research paper
  28. Corvera S, Czech MP. Energy's long game: thermogenic adipocytes and the metabolic diseases of modern life. Acad Biol. 2026;4. PMID: 42694970. research paper
  29. Sato S. Current and Future Perspectives on Adipo-Oncology: Roles of Adipocytes in Local and Systemic Tumor Regulation. Pathol Int. 2026;76:e70170. PMID: 42693631. research paper
  30. Frendo-Cumbo S, Zareifi D, Bigay J, Dias Araújo AR, Lapp A, Hansen M, et al. Functional annotation of insulin-responsive genes in human adipocytes reveals PLCXD1 as a lipid storage regulator. Nat Commun. 2026;17:9458. PMID: 42693141. research paper
  31. Rendon CJ, Rondini EA, Watts SW, Granneman JG, Contreras GA. Spatial Analysis of Perivascular Adipose Tissue Gene Expression with SABER-FISH. Methods Mol Biol. 2026;3036:45-57. PMID: 42681456. research paper
  32. Ghesmati Z, Rashid M, Fayezi S, Alizadeh E, Darabi M. Brown and white adipocyte like cells derived exosomes differentially regulate stemness, hormone secretion, apoptosis, and lipid metabolism in model cells. PLoS One. 2026;21:e0355955. PMID: 42678968. research paper
  33. Madhavan SR, Moore P, Ma Q, Atit RP. DPP4 Substrate Supplementation Protects From WNT-Induced Lipid Depletion in Dermal Adipocytes. Exp Dermatol. 2026;35:e70354. PMID: 42655870. research paper
  34. Zhu A, Zhou Y, Ren K, Sun C. IRF1 in Adipocytes Is Associated with Insulin Signaling and Mitochondrial Homeostasis in Diet-Induced Obesity. Int J Mol Sci. 2026;27:7332. PMID: 42653336. research paper
  35. Mikhaleva L, Martynova M, Gioeva Z, Shakhpazyan N, Chizhikov N, Pechnikova V, et al. SARIFA and Lipid Metabolic Reprogramming in Prostate Cancer: Fundamental Mechanisms, Tumor Microenvironment, and Novel Biomarker Prospects. Life (Basel). 2026;16:1304. PMID: 42652992. research paper
  36. Wang F, Meng Q, Gao J, Cui T, Qi Z, Zhao N, et al. GPR35 Mediates the Proliferation and Adipogenesis of Goat Intramuscular Preadipocytes Through the cAMP/PKA Signaling Pathway. Animals (Basel). 2026;16:2560. PMID: 42651965. research paper
  37. Liu Y, Zhang M, He Z, Sun L, Bai Y, Pan C, et al. Circular RNA circNID2 Promotes Bovine Adipogenesis via miR-339a/NNAT. Biomolecules. 2026;16:1113. PMID: 42650781. research paper
  38. Ylikomi T, Nees M. Ketogenic Diet as an Adjuvant in Epithelial Cancers: Mechanisms, Model Systems, and Translational Opportunities. Cancers (Basel). 2026;18:2600. PMID: 42649914. research paper
  39. Tsonov MN, Gish PE, Vahmani P. Effects of linoleic acid and its trans-10 biohydrogenation intermediates (trans-10, cis-12 conjugated linoleic acid and trans-10 18:1) on lipogenic gene expression and Δ9-desaturation indices in bovine intramuscular adipocytes. J Anim Sci. 2026;104:skag268. PMID: 42647272. research paper
  40. Gunsch G, Mishra G, Blaszkiewicz M, de Sousa E, Willows JW, Alltop KW, et al. Effects of 6-OHDA-Mediated Chemical Denervation of Sympathetic Axons in Inguinal Subcutaneous White Adipose Tissue. Diabetes Obes Metab. 2026;28:10459-10474. PMID: 42642346. research paper
  41. Liu C, Tian Z, Wang Z. [miR-454-3p suppresses the proliferation of abdominal preadipocytes in broilers]. Sheng Wu Gong Cheng Xue Bao. 2026;42:3564-3579. PMID: 42638056. research paper
  42. Shi J, Abdel-Ghany S, Abdel-Fattah M, Hu X, Wadan AS, Sabit H. Cancer-associated adipocytes: metabolic reprogramming, crosstalk and therapeutic implications in tumor progression. Signal Transduct Target Ther. 2026;11:347. PMID: 42637735. research paper
  43. Wei X, Shan X, Yang L, Zhao X, Ma Y, Zhang P, et al. Transcriptome and Functional Analysis Uncover the Role of ADCY5 in Bovine Adipogenesis. Anim Genet. 2026;57:e70191. PMID: 42637538. research paper
  44. Di Fulvio M. The aryl hydrocarbon receptor as a tissue-specific modulator of insulin sensitivity: evidence from conditional deletion studies. Toxicol Sci. 2026;209:kfag103. PMID: 42635556. research paper
  45. Brown RDR, Weigel C, Vijayan Y, Tyc KM, Carter C, Green CD, et al. Sphingosine kinase 2 regulates adipocyte browning and whole-body metabolism. Sci Adv. 2026;12:eaec7066. PMID: 42627910. research paper
  46. Braunsperger A, Tischer D, Soriano-Arroquia A, Schönfelder M, Georgiadi A, Wackerhage H. Exercise and Fat: A Primer. Sports Med Open. 2026;12:121. PMID: 42627570. research paper
  47. Li A, Yue B, Hu H, Li X, Li Z, Ma Y, et al. Adipose-specific Kdm2a deficiency promotes ferroptosis-associated features and hypertrophic remodeling of adipocytes. J Lipid Res. 2026;67:101127. PMID: 42624370. research paper
  48. Jiang X, Avellino A, Yu J, Liu S, Zhao L, Wang Z, et al. Targeting circulating fatty acid-binding protein 4 ameliorates obesity-associated hepatic steatosis. JHEP Rep. 2026;8:101999. PMID: 42624369. research paper
  49. Dos Santos FCF, Eskridge KR, Laws MJ, Flaws JA, Graceli JB. Effects of phthalates on mammalian adipose tissue. Toxicol Sci. 2026;209:kfag111. PMID: 42623126. research paper
  50. Zhang YR, Zhou ZY, Xia JN, Wang YF, Zhang ZY, Liao LL, et al. [Effect of electroacupuncture on hepatic autophagy in obese mice based on the AMPK/mTOR/ULK1 pathway]. Zhen Ci Yan Jiu. 2026;51:955-967. PMID: 42621706. research paper
  51. Yin J, Rusch DB, Bhatta JS, Merritt DM, Weaver LN. Genomic Profiling of Estrogen-Related Receptor Identifies Adult Adipocyte-Specific Targets in Drosophila. bioRxiv. 2026. PMID: 42619948. research paper
  52. Deng X, Wu Y, Chen X, Zeng J, Li W, Wang X, et al. Polygonati Odorati Rhizoma Extract Ameliorates Obesity and Insulin Resistance Potentially Through Modulation of the TLR4/NLRP3 Signaling Pathway. Diabetes Metab Syndr Obes. 2026;19:610538. PMID: 42610059. research paper
  53. Kang BM, Choi HS, Kim BR, Youn SW, Kwon HJ, Lee JK, et al. Inhibition of fatty acid-binding protein 4 alleviates psoriasis-like skin inflammation by modulating macrophage polarization. Front Immunol. 2026;17:1830077. PMID: 42609463. research paper
  54. He Y, Pan L, Ping W, Meng C, Meng X, Guo Y, et al. An ANGPTL8-AKT2-mTOR Axis Drives Adipose Senescence and Aging-Related Functional Decline. Aging Cell. 2026;25:e70671. PMID: 42605193. research paper
  55. Song R, He J, Ahmad AA, Gui L, Hou S, Yang C. Dietary urea levels induce morphological damage of cells, lipid metabolism disorders, and ammonia accumulation in subcutaneous fat in Tibetan sheep. Front Vet Sci. 2026;13:1887140. PMID: 42601942. research paper
  56. Dardi M, Berardo C, Pelizzo G, Bonnet M, Destro F, Capelo G, et al. In vitro modeling of adipogenesis using MSCs from subcutaneous adipose tissue to explore the cellular and molecular mechanisms underlying pediatric obesity and obesogenic memory. Obes Facts. 2026:1. PMID: 42599843. research paper
  57. Ma YX, Lin M, Nan Y, Li NN, Liu B, Wang HR, et al. Obesity-driven low-grade chronic inflammation as a mechanistic bridge to chronic pain: from adipose tissue remodeling to central sensitization. Front Immunol. 2026;17:1889437. PMID: 42597587. research paper
  58. Kim S, Nguyen PA, Park KS, Cha SK, Namkung J. Orai1-mediated Ca2+ entry regulates lipolysis and mitochondrial activation in brown adipose thermogenesis. Exp Mol Med. 2026;58:2781-2791. PMID: 42595867. research paper
  59. Fu Z, Yang C, Huang Q, Pan Y, Wu H, Cai Y, et al. An N-salicyloyl tryptamine derivative (compound 18) improves spermatogenic impairment in obese mice via regulating insulin resistance and enhancing Sertoli cell glycolysis. Mol Cell Endocrinol. 2026;622:112894. PMID: 42595295. research paper
  60. Gholizadeh M, Noushzadeh Z, Movahed S, Aghapour B, Kolahi A, Mirmiran P. The effect of ascorbic acid supplementation on plasma leptin and adiponectin levels: Systematic review of in vivo and in vitro studies. Curr Ther Res Clin Exp. 2026;105:100838. PMID: 42592588. research paper
  61. Ye HL, Wang YN, Li GA, Jin XH, Li Y, Jin YH. A novel continuous-progression CKM model combined with multi-omics data integration identifies lipid metabolic drivers of disease progression. Front Endocrinol (Lausanne). 2026;17:1910505. PMID: 42591226. research paper
  62. García-Dávila S, Cifuentes C, Gracia I, Gómez LA, Llorens S. Effect of Combined Grape Seed (Vitis vinifera) and Garlic (Allium sativum) Extracts on Adipogenesis in the 3T3-L1 Preadipocyte Line. Int J Mol Sci. 2026;27:7043. PMID: 42589693. research paper
  63. Chávez-Ortega MP, Peña-Peña M, Carbó R, Medina-Urrutia A, Osorio-Alonso H, Jiang B, et al. Adipose Tissue Heterogeneity: Depot-Specific Location and Functional Specialization in Obesity-Related Disease. Int J Mol Sci. 2026;27:6693. PMID: 42589349. research paper
  64. Pampaloni F, Piraccini BM, Bruni F, Quadrelli F, Misciali C, Merlini L, et al. Hair Follicle Microenvironment Changes in Collagen VI-Myopathy Patients with Alopecia. Cells. 2026;15:1351. PMID: 42587761. research paper
  65. Gyurina K, Korpás KL, Bajusz-Rácz A, Radványi , Sasi-Szabó L, Méhes G, et al. FAM153A Is a Novel Biomarker of Human Thermogenic Adipocytes. Cells. 2026;15:1321. PMID: 42587731. research paper
  66. Füchtbauer LM, Senn JR, Baumann CS, Isenrich AL, Gaynor TL, Schläfli R, et al. Beta2-adrenergic stimulation by fenoterol increases energy expenditure without activating human brown adipose tissue. Cell Metab. 2026;38:1802-1814.e4. PMID: 42586060. research paper
  67. Kleißen J, Goerdeler C, Aldehoff AS, Karkossa I, Didio A, Schmidt J, et al. Halogenated bisphenol A alternatives inhibit aldo-keto reductase 1C1 and induce metabolic alterations in human adipocytes. J Hazard Mater. 2026;515:143238. PMID: 42585961. research paper
  68. An SH, Park JY, Lee SJ. KPV attenuates adipogenesis and lipid metabolism through modulation of ROS-mediated AKT/mTORC1/PPARγ signaling. Tissue Cell. 2026;104:103837. PMID: 42585803. research paper
  69. Sasankan D, Mohan R. The Mechanobiology of Adipocyte Hypertrophy: Cytoskeletal Remodelling as a Driver of Insulin Resistance in Obesity. Cell Biochem Funct. 2026;44:e70283. PMID: 42583807. research paper
  70. Wang HR, Lv XH, Sun Y, Gu ZC, Lin M, Guan L, et al. Extracellular vesicle-mediated immune-metabolic crosstalk: research advances in inflammatory regulation and the pathogenesis of metabolic diseases. Front Immunol. 2026;17:1884606. PMID: 42583072. research paper
  71. Zhao Y, Wang F. Stigmasterol ameliorates obesity-associated insulin resistance by activating the PPARγ pathway and alleviating oxidative stress. Front Endocrinol (Lausanne). 2026;17:1888104. PMID: 42582192. research paper
  72. Divoux A, Erdos E, Whytock KL, Osborne TF, Smith SR. Impaired adipogenesis and lipid storage capacity in subcutaneous adipose tissue of patients with PMOS. JCI Insight. 2026;11:e199981. PMID: 42579798. research paper
  73. Sheng J, Qi S, Chan M, Wang E, Han X, Hsueh WA, et al. Substrate-Selective Lipolysis Facilitates Unsaturated TAG Accumulation in Obesity. Diabetes. 2026;75:1781-1793. PMID: 42579480. research paper
  74. Yan Y, Chen L. Organelle contact sites as spatial regulators of lipid fate in adipose tissue metabolic disease. Life Sci. 2026;403:124624. PMID: 42567497. research paper
  75. Liu P, Long K, Wang Y, Sulaiman JE, Wang B, Zhou X, et al. MDM2 deletion and its associated p53 activation in subcutaneous white adipose tissue induce hepatic fibrosis via galectin-3 in a mouse model. Metabolism. 2026;184:156726. PMID: 42567474. research paper
  76. Narayanasamy R, Sanders MA, Zhang H, Moreno-Torres M, Ramseyer VD, Wei HG, et al. ABHD4-2: a cardiolipin-selective phospholipase of the outer mitochondrial membrane. J Lipid Res. 2026;67:101119. PMID: 42562323. research paper
  77. Sasaki R, Matsukura H, Meguro R, Bai L, Sawai K, Sugano E, et al. Immortalization of Adipose-Derived Stromal Cells From Japanese Black Cattle. Cell Biol Int. 2026;50:e70194. PMID: 42559951. research paper
  78. Cai S, Ma M, Zhu Y, Shi M, Dai X, Wang Y, et al. Chemokine receptor CCR1 restrains adipose tissue remodelling via cAMP/PKA/CREB signalling and adipocyte‒macrophage crosstalk in mice. Clin Transl Med. 2026;16:e70762. PMID: 42557944. research paper
  79. Fryk E, Silva VRR, Bauzá-Thorbrügge M, Strindberg L, Kullberg J, Ahlström H, et al. Plasma neuropilin-1 is associated with a favorable lipid profile and insulin sensitivity in a population-based sample of 50-year-old individuals. Sci Rep. 2026;16:24169. PMID: 42557353. research paper
  80. Chu Y, Zhang Y, Chu C, Liu Y, Tang J, Yu F, et al. Endothelial TRPV4 mitigates obesity-induced metabolic dysfunction via Ca2+-dependent eNOS phosphorylation. Int Immunopharmacol. 2026;187:117202. PMID: 42546516. research paper
  81. Dong G, Spyropoulos G, Adak S, Zhang Q, Zhang W, Speck SL, et al. Adipose Tissue Palmitoylation Cycling Mediates Insulin Resistance and Preservation of β-Cell Function in Mice. Diabetes. 2026;75:1767-1780. PMID: 42546226. research paper
  82. Sebestyén A, Varga V, Szalai F, Miyaura R, Förhécz N, Csikós B, et al. CD36-mediated lipid rewiring in the metabolic adaptation of tumour ecosystems. FEBS J. 2026. PMID: 42543461. research paper
  83. Xu JQ, Cai ZW, Pang ZY, Chen WJ, Chen JY, Wang DJ, et al. [Mechanism of total flavonoids from Smilacis Glabrae Rhizoma against obesity-associated colorectal cancer via regulation of fatty acid oxidation]. Zhongguo Zhong Yao Za Zhi. 2026;51:3818-3829. PMID: 42543372. research paper
  84. Uslu M, Biçer O, Önaloğlu Y, Balcı E, Güleryüz Y, Acar A, et al. Dose-dependent protective effects of punicalagin on steroid-induced osteonecrosis in a rat model. Jt Dis Relat Surg. 2026;37:785-799. PMID: 42542923. research paper
  85. Laowittawat C, Boonprasert P, Sawektreeratana N, Hongthong S, Reutrakul V, Kuhakarn C, et al. Potent Anti-adipogenic Activity of Cyclopeptide Mallotumide A on Murine 3T3-L1 Adipocytes. ACS Omega. 2026;11:44169-44182. PMID: 42540331. research paper
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